Farmacoeconomía de la terapia biológica de las espondiloartropatías
DOI:
https://doi.org/10.18270/rce.v5i5.1422Palabras clave:
espondiloartropatía, farmacoeconomía, terapia biologicaResumen
Las espondiloartropatías (EAS) son un grupo de enfermedades reumatológicas crónicas e inflamatorias. El diagnóstico de estas patologías frecuentemente es tardío; su curso evolutivo es progresivo, con el consecuente deterioro funcional y discapacidad, con compromiso articular que conlleva a la disminución en la calidad de vida con un alto impacto socioeconómico. La mayoría de los estudios farmacoeconómicos se enfocan en los aspectos de la sociedad o del proveedor de los servicios de salud, y sólo una minoría toma en cuenta la perspectiva del paciente, de donde se pueden estimar los recursos médicos directos e indirectos que el paciente y su familia destinan al tratamiento de la enfermedad. La terapia biológica ha demostrado control de todos los aspectos de la actividad de la enfermedad, incluyendo reactantes de fase aguda, dolor y rigidez, capacidad funcional, movilidad espinal, artritis periférica y entesitis.
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Referencias bibliográficas
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2.
Valle RR, Jáuregui E, Otero W, Vélez P et ál. Recomen
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daciones del Comité de Expertos de la Asociación
Colombiana de Reumatología para el empleo de la
terapia biológica en las espondiloartropatías. Revista
Colombiana de Reumatología. 2005; 12 (2): 95-106.
3.
Londoño JD, Valle RR. Es hora de tomar conciencia sobre
el tratamiento de las espondiloartropatías. Editorial Revista
Colombiana de Reumatología. 2003; 10 (4): 245-248
4.
Collantes E, Muñoz E. En: Valle RR, Londoño JD Eds.
Espondiloartropatías: Validación de criterios diagnós
-
ticos y de clasificación de las espondiloartropatías.
Primera edición. Asociación Colombiana de Reumato
-
logía. 2007: 119-128
5.
Khan MA. Thoughts concerning the early diagnosis of
ankylosing spondylitis. Clin Exp Rheumatol 2002; 20
(Suppl.
28): S6-S10.
6.
Erturk M, Alaca R, Tosun E, Duruöz MT.
Evaluation
of the Amor and ESSG classification criteria for spon
-
dylarthropathies in a turkish population. Rev Rhum
(Engl Ed.) 1997; 64: 293-300.
7.
Boyer GS, Templin DW, Bowler A et ál.
Spondylar-
Spondylar
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thropathy in the community: Clinical syndromes and
disease manifestations in alaskan eskimo populations.
J Rheumatol 1999; 26: 1537-1544.
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Amor B, Dougados M, Mijiyawa M. Critères de classica
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D`Orazio A, Correa MA, Rosemffet M, cols. Terapia
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Torres AC, Knaul FM. Determinantes del gasto de
bolsillo en salud e implicaciones para el aseguramiento
universal en México: 1992-2000. Calidoscopio de la
Salud 2004: 209-225.
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Boonen A, Van der Heijde D, Landewe R, et ál. Costs of
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Mexico. Gac Med Mex 2008; 144: 225-231.
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-
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Reductions in health-related quality of life in patients
with ankylosing spondylitis and mprovements with
etanercept therapy.
Arthritis Rheum 2005; 53: 494-501.
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Health-
related quality of health outcomes in patients with
active ankylosing spondylitis treated with adalimumab:
Results from a randomized controlled study. Arthritis
Rheum 2007; 57: 1050-7.
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Persistent clinical
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North Am 2003; 29: 185-202.
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Radiographic
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years of treatment with the tumour necrosis factor alpha
antibody Infliximab. Ann Rheum Dis 2005; 64: 1462-6.
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Garret S, Jenkinson T, Kennedy LG, Whitelock H, Gains
-
ford P, Calin A. A new approach to defining disease
status in ankylosing spondylitis. The BATH Ankylosing
Spondylitis Disease Activity Index. J Rheumatol 1994;
21: 2286-91.
30.
Calin A, Garret S, Whitelock H et ál. A new approach
to defining functional ability in ankylosing spondylitis:
The development of the BATH Ankylosing Spondylitis
Functional Index. J Rheumatol 1994; 21: 2281-85.
31.
Jenkinson TR, Mallory PA, Whitelock HC, Kennedy LG,
Garret SL, Calin A. Defining spinal mobility in ankylo
-
sing spondylitis (AS). The Bath AS Metrology Index. J
Rheumatol 1994; 21: 1694-8.
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Braun J, Baraliakos X, Listing J, Fritz C, et ál. Persis
-
tent clinical efficacy and safety of anti-tumour necrosis
factor a therapy with infliximab in patients with ankylo
-
sing spondylitis over 5 years: evidence for different
types of response. Ann Rheum Dis. 2008; 67: 340-345.
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Six month result
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Long-Term efficacy and safety
of etanercept after readministration in patients active
ankylosing spondylitis. Rheumatology Oxford 2005;
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human tumor necrosis factor receptor (etanercept) for
treating ankylosing spondylitis: Randomized, contro
-
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ankylosing Spondylitis. Ann Rheum Dis 2004; 63: 1594-600.
37.
Davis JC Jr, van der Heijde D, Braun J, et ál. Sustained
durability and tolerability of etanercept in ankylosing
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Treatment of active
ankylosing spondylitis with infliximab: A randomized
controlled multicentre trial. Lancet 2002; 359: 1187-93.
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Van Den Bosch F, Kruithof E, Baeten D, et ál. Randomized
double-blind comparison of chimeric monoclonal anti
-
body to tumor necrosis factor alpha (Infliximab) versus
placebo in active spondylarthropathy. Arthritis Rheum
2002; 46: 755-65.
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Van der Heijde D, Dijkmans B, Geusens P, et ál.. Effi
-
cacy and safety of Infliximab in patines with ankylosing
spondylitis: Results of a randomized, placebo-contro
-
lled trial (ASSERT).
Arthritis Rheum 2005; 52: 582-91.
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and safety of infliximab in the treatment of Ankylosing
Spondylitis: An open, observational, extension study
of a three-month, randomized, placebo.controlled trial.
Arthritis Rheum 2003; 48: 2224-33.
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Braun J, Brandt J, Listing J, et ál.
Two year maintenance
of efficacy and safety of Infliximab in the treatment of
Ankylosing Spondylitis.
Ann Rheum Dis 2005; 64: 229-34
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Braun J, Baraliakos X, Brandt J, et ál..
Persistent clinical
response to the anti-TNF-alpha antibody Infliximab in
patiens with Ankylosing Spondylitis over 3 years. Rheu
-
matology Oxford 2005; 44: 670-6.
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terapia biológica en las espondiloartropatías. Asocia
-
cion Colombiana de Reumatología. 2005: 1-29
González LA, Londoño JD, Valle RR. Disgnóstico
temprano de las espondiloartropatías. Revista Colom
-
biana de Reumatología. 2005; 12 (3): 241-262.
2.
Valle RR, Jáuregui E, Otero W, Vélez P et ál. Recomen
-
daciones del Comité de Expertos de la Asociación
Colombiana de Reumatología para el empleo de la
terapia biológica en las espondiloartropatías. Revista
Colombiana de Reumatología. 2005; 12 (2): 95-106.
3.
Londoño JD, Valle RR. Es hora de tomar conciencia sobre
el tratamiento de las espondiloartropatías. Editorial Revista
Colombiana de Reumatología. 2003; 10 (4): 245-248
4.
Collantes E, Muñoz E. En: Valle RR, Londoño JD Eds.
Espondiloartropatías: Validación de criterios diagnós
-
ticos y de clasificación de las espondiloartropatías.
Primera edición. Asociación Colombiana de Reumato
-
logía. 2007: 119-128
5.
Khan MA. Thoughts concerning the early diagnosis of
ankylosing spondylitis. Clin Exp Rheumatol 2002; 20
(Suppl.
28): S6-S10.
6.
Erturk M, Alaca R, Tosun E, Duruöz MT.
Evaluation
of the Amor and ESSG classification criteria for spon
-
dylarthropathies in a turkish population. Rev Rhum
(Engl Ed.) 1997; 64: 293-300.
7.
Boyer GS, Templin DW, Bowler A et ál.
Spondylar-
Spondylar
-
thropathy in the community: Clinical syndromes and
disease manifestations in alaskan eskimo populations.
J Rheumatol 1999; 26: 1537-1544.
8.
Amor B, Dougados M, Mijiyawa M. Critères de classica
-
tion des spondylarthropathies. Revue du Rhumatis et
des Maladies Osteoarticulaire. 1990; 57: 85-89.
9.
Calin A, Porta J, Fries JF, Schurmann DJ. Clinical history
as a screening test for ankylosing spondylitis. JAMA
1977; 237: 2613-2614.
10.
D`Orazio A, Correa MA, Rosemffet M, cols. Terapia
biológica en espondiloartropatías seronegativas:
Experiencia en 21 pacientes. Revista Argentina de
Reumatología. 18 (2): 33-37.
11.
Clegg D. Treatment of ankylosing spondylitis. J Rheu
-
matol 2006; 33: 24-31.
12.
Ruof J, Hûlsemann JL, Stucki L. Evaluation of costs
in rheumatic diseases: A literature review. Curr Opin
Rheumatol 1999; 11: 104-109.
13.
Lapsley HM, March LM, Tribe KL, Cross MJ, et ál. Living
with rheumatoid arthritis: Expenditures health status
and social impact on patients. Ann Rheum Dis 2002;
61: 818-821.
14.
Torres AC, Knaul FM. Determinantes del gasto de
bolsillo en salud e implicaciones para el aseguramiento
universal en México: 1992-2000. Calidoscopio de la
Salud 2004: 209-225.
15.
Boonen A, Van der Heijde D, Landewe R, et ál. Costs of
ankylosing spondylitis in three European countries: The
patients perspective. Ann Rheum Dis 2003; 62: 741-747.
16.
Mould-Quevedo J, Pelaez-Ballestas I, Vazquez-Mellado
J, et ál. El costo de las principales enfermedades reumá
-
ticas inflamatorias desde la perspectiva del paciente en
Mexico. Gac Med Mex 2008; 144: 225-231.
17.
Barlow JH, Wright CC, Williams B, et ál. Work disabi
-
lity among people with ankylosing spondylitis. Arthritis
Care Res 2001; 45: 429-437.
18.
Ariza-Ariza R, Henandez-Cruz B, Navarro-Sarabia F.
Physical function and health-related quality of life of
spanish patients with ankylosing spondylitis. Arthritis
Care Res 2003; 49: 483-487.
19.
Ara RM, Packham JC, Haywood KL. The direct health
-
care costs associated with ankylosing spondylitis
patients attending a UK secondary care rheumatology
unit. Rheumatology 2008; 47:68-71.
20.
Khan MA. Ankylosing spondylitis: Clinical aspects. In:
Calin A, Taurog J, eds. The spondyloarthritides. Oxford:
Oxford University Press, 1998.
21.
Van der Heijde D, Djikmans B, Geusens P et ál.
Effi-
Effi
-
cacy and safety of infliximab in patients with ankylosing
spondylitis. Results of a randomized, placebo – contro
-
lled trial (ASSERT). Arthritis Rheum 2005; 52: 582-91.
22.
Davis JC Jr, Van der Heijde D, Braun J et ál. Enbrel
ankylosing spondylitis study group. Recombinant
human tumour necrosis factor receptor etanercept for
treating ankylosing spondylitis: A randomized contro
-
lled trial. Arthritis Rheum 2003; 48: 3230-6.
23.
Van der Heijde D, Kivitz A, Schiff MH et ál. Efficacy
and safety of adalimumab in patients with ankylo
-
sing spondylitis. Results of a multicentre, andomized,
doubleblind, placebo-controlled trial. Arthritis Rheum
2006; 54: 2136-46.
24.
Davis JC, van der Heijde, Dougadaos M, Wooley JM.
Reductions in health-related quality of life in patients
with ankylosing spondylitis and mprovements with
etanercept therapy.
Arthritis Rheum 2005; 53: 494-501.
25.
Davis JC Jr, Revicki D, van der Heijde DM et ál.
Health-
related quality of health outcomes in patients with
active ankylosing spondylitis treated with adalimumab:
Results from a randomized controlled study. Arthritis
Rheum 2007; 57: 1050-7.
26.
Braun J, Baralikos X, Brandt J et ál.
Persistent clinical
response to the anti-TNFalpha antibody infliximab in
patients with ankylosing spondylitis over 3 years. Rheu
-
matology 2005; 44: 670-6.
27.
Bresnihan B, Cunnane G. Infection complications asso
-
ciated with the use of biologic agents. Rheum Dis Clin
North Am 2003; 29: 185-202.
28.
Baralikos X, Listing J, Rudwaleit M et ál..
Radiographic
progression in patients with ankylosing spondylitis after 2
years of treatment with the tumour necrosis factor alpha
antibody Infliximab. Ann Rheum Dis 2005; 64: 1462-6.
29.
Garret S, Jenkinson T, Kennedy LG, Whitelock H, Gains
-
ford P, Calin A. A new approach to defining disease
status in ankylosing spondylitis. The BATH Ankylosing
Spondylitis Disease Activity Index. J Rheumatol 1994;
21: 2286-91.
30.
Calin A, Garret S, Whitelock H et ál. A new approach
to defining functional ability in ankylosing spondylitis:
The development of the BATH Ankylosing Spondylitis
Functional Index. J Rheumatol 1994; 21: 2281-85.
31.
Jenkinson TR, Mallory PA, Whitelock HC, Kennedy LG,
Garret SL, Calin A. Defining spinal mobility in ankylo
-
sing spondylitis (AS). The Bath AS Metrology Index. J
Rheumatol 1994; 21: 1694-8.
32.
Braun J, Baraliakos X, Listing J, Fritz C, et ál. Persis
-
tent clinical efficacy and safety of anti-tumour necrosis
factor a therapy with infliximab in patients with ankylo
-
sing spondylitis over 5 years: evidence for different
types of response. Ann Rheum Dis. 2008; 67: 340-345.
33.
Brandt J, Khariouzov A, Listing J, et ál..
Six month result
of a double-blind, placebo-controlled trial of Etanercept
in patients with active ankylosing spondylitis. Arthritis
Rheum 2003; 48: 1667-75.
34.
Brandt J, Listing J, et ál..
Long-Term efficacy and safety
of etanercept after readministration in patients active
ankylosing spondylitis. Rheumatology Oxford 2005;
44: 342-8.
35.
Davis JC Jr, van der Heijde D, Braun J, et ál. Recombinant
human tumor necrosis factor receptor (etanercept) for
treating ankylosing spondylitis: Randomized, contro
-
lled trial. Arthritis Rheum 2003; 48: 3230-6.
36.
Calin A, Dijkmans BA, Emery P, et ál. Outcomes of a
multicentre randomized clinical trial of etanercept to treat
ankylosing Spondylitis. Ann Rheum Dis 2004; 63: 1594-600.
37.
Davis JC Jr, van der Heijde D, Braun J, et ál. Sustained
durability and tolerability of etanercept in ankylosing
Spondylitis for 96 week. Ann Rheum Dis 2005; 64: 1557-62.
38.
Braun J, Brandt J, Listing J, et ál.
Treatment of active
ankylosing spondylitis with infliximab: A randomized
controlled multicentre trial. Lancet 2002; 359: 1187-93.
39.
Van Den Bosch F, Kruithof E, Baeten D, et ál. Randomized
double-blind comparison of chimeric monoclonal anti
-
body to tumor necrosis factor alpha (Infliximab) versus
placebo in active spondylarthropathy. Arthritis Rheum
2002; 46: 755-65.
40.
Van der Heijde D, Dijkmans B, Geusens P, et ál.. Effi
-
cacy and safety of Infliximab in patines with ankylosing
spondylitis: Results of a randomized, placebo-contro
-
lled trial (ASSERT).
Arthritis Rheum 2005; 52: 582-91.
41.
Braun J, Brandt J, Listing J, et ál.
Long term efficacy
and safety of infliximab in the treatment of Ankylosing
Spondylitis: An open, observational, extension study
of a three-month, randomized, placebo.controlled trial.
Arthritis Rheum 2003; 48: 2224-33.
42.
Braun J, Brandt J, Listing J, et ál.
Two year maintenance
of efficacy and safety of Infliximab in the treatment of
Ankylosing Spondylitis.
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Publicado
2016-08-19
Cómo citar
García C., J. C. (2016). Farmacoeconomía de la terapia biológica de las espondiloartropatías. Revista Colombiana De Enfermería, 5, 29–40. https://doi.org/10.18270/rce.v5i5.1422
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